Signs Wellbutrin is Working (A guide)

In this brief guide, we will discuss some signs Wellbutrin is working, as well as other things related to Wellbutrin that you should know.

Signs Wellbutrin is Working

Signs wellbutrin is working may be many, you may feel like you are seeing a decrease in some of your somatic symptoms and even though you may still feel depressed and the motivation levels may be very low still, you may not be sleeping and eating as poorly, and your sleep will start being more restful.

Another thing you may notice that may make for a good sign wellbutrin is working is that you may experience a more restful sleep, and when you wake up you may not feel as foggy, because wellbutrin significantly improves the quality of your sleep so that you feel much better on wakefulness.

Lastly, a sign wellbutrin is working on the somatic symptoms of depression may be a better sexual drive, and the person may start feeling like they have a desire for sexual intimacy again, which is something that goes down right away.

Other somatic symptoms of depression wellbutrin may start working on from the start are fatigue, random aches and pains and a general feeling of malaise.

Wellbutrin may work on the somatic symptoms of depression within the first 2 weeks or so of starting it, and sometimes it may take up to 3 weeks as well.

On the other hand it may take about 4-6 weeks of Wellbutrin to start working on the psychological symptoms of depression.

The first signs wellbutrin is working on the psychological and emotional symptoms of depression include a decrease in the depressed mood, and feeling like the fogginess that has prevailed for so long is starting to abate little by little.

The individual might not feel happy overnight, but they may start feeling like they are not feeling as bogged down by sadness, and they may start feeling some motivation to do their own chores and take showers or take care of the personal errands they may have been ignoring while depressed.

The individual taking wellbutrin may not recognize the signs right away either, and they may find that they are just doing things without realizing it, and functioning better than they have been for some time.

Another sure sign wellbutrin is working on depression may be a renewed feeling of pleasure in things that may have been joyless to the person while they were depressed.

Usually when the person does not notice any difference in the symptoms of depression even by the 6th week, their doctor might change their prescription to another antidepressant.

If you’re facing this, it may be a good idea to seek the help of a therapist or other mental health professional. You can find a therapist at BetterHelp who can help you learn how to cope and address it.

Wellbutrin Side Effects

Following are the common side effects of Wellbutrin:

  • Nausea
  • Headache
  • Weight loss
  • Dizziness
  • Dry mouth
  • Trouble sleeping
  • Fast heartbeat
  • Sore throat.
  • Constipation

Some rare Wellbutrin side effects include the ones given below, but it is important to remember that only about 10% of the people who take Wellbutrin experience these side effects, and if you do experience them you need to seek medical help right away.

  • Skin rash
  • Stomach pain
  • Muscle pain
  • Sweating
  • Ringing in the ears
  • Shakiness
  • Thought disturbances
  • Anxiety
  • Angle closure glaucoma

How does Wellbutrin work?

Wellbutrin is a class of drugs that work on the neurotransmitters norepinephrine and dopamine, and it is considered the Dopamine reuptake inhibitor (NDRI).

Wellbutrin usually works by keeping the neurotransmitters norepinephrine and dopamine available for longer than they would in mental illnesses so that the brain’s neurons may have more time to receive them. 

Wellbutrin is often used for ADHD as well, and the reason for that is the way wellbutrin works with norepinephrine and dopamine, both of which may be maladaptive in case of someone with ADHD.

The way Wellbutrin works may be by improving concentration, focus, and other ADHD symptoms. 

However, Wellbutrin does not work directly on serotonin like other antidepressants, it modulates the symptoms of depression through the regulation of dopamine and norepinephrine.

Wellbutrin Reviews

Here are some of the best and most comprehensive Wellbutrin reviews to help you understand the functioning of this drug in a better way:

“For Depression: “This medicine Wellbutrin just made me sleepy and irritable/ depressed. Didn’t have any side effects like dry mouth or excessive energy. It kinda made my depression worse. Keep looking for the right med. It works for some but unfortunately didn’t work for me.”

“For Depression: “I was a 250 pound fat and happy married man until I was diagnosed with stage 3B cancer. My wife and kids convinced me to see a Psych and get treated. Anyway, he started my on Wellbutrin (BUPROPION generic) at 200mg per day. He said this med has been around a long time and it’s very safe and effective. Note that I don’t have Anxiety. After a week on BUPROPION, I would sing on the way to work and was unable to take the smile off my face. After about 6 months these feelings wore off, but I was still better than before. My Psych upped the dosage to 300mg per day. I take two 100mg pills at 9am and then one 100mg pill at 230pm. Overall, I’m happy. It worked for me. Only side effects are a little insomnia twice per month and ringing in my ears 4 times per month, which lasts for hours each time. The ringing is very low. I get my meds Generic for a 90 day supply each time and my insurance charges me $24 for that 90 day supply (300mg/day).”

“For Major Depressive Disorder: “This Wellbutrin is the only antidepressant I can tolerate. It seems to be one of the more stimulating ones, which I need because of my hypothyroidism. I can’t handle a high dose so have stuck with 100-150mg 1x a day for over 5 years and I don’t usually feel depressed. If I miss a dose I feel a little down and lethargic. I’ve smoked on and off for 20+ years and I can’t say it helps me in that area–at least not at the dose I’m taking. I’ve been told I am wired differently than most (O-) and so far this is the only mostly effective antidepressant I have ever taken without side effects.”

“For Depression: “I’m on day 3 of wellbutrin. So far it’s been miserable. I’m on the lowest dose and still having horrible stomach side effects. I can’t eat, I have no appetite, severe diarrhea with intense stomach pain. I’m also exhausted but can’t seem to sleep more than a few hours at a time. My mouth is dry and my eyeballs feel like sandpaper. And to top it all off, just looking at my husband arouses me. I’d actually enjoy that side effect if I could stay off the toilet. I’m gonna try to stick it out in hopes that this will pass. I know I need to give it some time.”

How does Wellbutrin Make you feel? (Reddit Reviews)

To understand how Wellbutrin makes you feel, here is a compilation of some honest things people say on reddit about this drug:

“I, myself, am a confirmed positive responder to Wellbutrin. Whenever I’ve taken my first dose after a period of not taking it, the feeling is one of slight tiredness, less edginess, dullness, maybe even relaxation. Also, improved sleep the following night. These effects would be consistent with a drop (or non-increase) in cortisol.”

“I found Wellbutrin to be too activating. Tight chest, short of breath. And still just as tired”

“Same. Anxiety was so bad I couldn’t stop myself from vomiting”

“For me, I had about 2 great weeks on Wellbutrin, and then my anxiety shot through the roof. It was frustrating to have to come off, but I went from depressed, couldn’t get out of bed, to energetic and normal for two weeks, to a high strung, emotional wreck that span.”

“Mine wasn’t immediate, but it’s been very very very very helpful. I’ve been on it since June of last year, and I feel like I’m rediscovering myself since having my kid six years ago. I’m so grateful for this.”

“I responded positively to a low dose of Wellbutrin. I have been diagnosed with PB II and it didn’t make me hyper; in fact I hardly noticed the effects — it was only in retrospect I realized that I was leaving the house, interacting with people, and getting things done.

Sadly after about a month it amped up my tinnitus to an unbearable extent. I became concerned (rightly or wrongly) that this might become permanent so I stopped taking it. Fortunately the tinnitus slowly subsided, Unfortunately also the depression crept back.”

“My first day was energizing, but not in a bad way. No side effects on the first day. It just felt like a nice cup of coffee. Then I had side effects for the next 3 days or so (low grade headache and low appetite), but then they went away. I’m now in my 3rd week and I feel more in control of my emotions, less depressed, more energized. Motivation seems to be on the rise, and hopefully it helps with focus as well. The “activating” effects haven’t increased my anxiety. I’m really liking it. No side effects whatsoever, and no “drugged” feeling. I basically feel normal. It’s helping me and I’m not even at the 6 week mark (plus I’m only on 150mg), so I’m pretty excited for that.”


In this brief guide, we discussed some signs Wellbutrin is working, as well as other things related to Wellbutrin that you should know.

Wellbutrin is a great medicine that is meant to provide relief for symptoms of depression, and when the person first starts taking it they may be anxious for it to start working immediately, but like most antidepressants it may take some time.

Wellbutrin is an often prescribed medicine for depression and it may be available under different brand names in different parts of the world.

If you have any questions or comments about signs wellbutrin is working, please feel free to reach out to us at any time.

Frequently Asked Questions (FAQs): Signs Wellbutrin is working

How does Wellbutrin make you feel?

Wellbutrin can help with some of the somatic symptoms of depression relatively soon after starting it, and it can make you feel hungry and sleepy, but it can also make you feel anxious, restless or agitated.

How do you know if your antidepressant is working?

To know if your antidepressant is working you can pay attention to your somatic symptoms, if you feel that you are sleeping better than you have been since you have been depressed, or if you are eating better and feeling hungrier than you have been, it means that the antidepressant you are taking is working.

Another way to know if your antidepressant is working is to check if you are feeling rested after a full night’s rest, because this is something that gets hampered when you are depressed.

How do you know if Wellbutrin isn’t working?

To know if Wellbutrin isn’t working you need to check if you have the following symptoms:

Having trouble sleeping.
Appetite issues.
Feeling the exact same level of sadness, anxiety, or irritability even after several weeks or months of starting the medication.
Feeling slightly better, but the depression still affects your ability to function.

What to expect when you start taking Wellbutrin?

When you start taking Wellbutrin, you can expect to see some changes in your sleep and appetite levels in the first couple of weeks, but you should also be ready for some side effects like nausea or nicotine cravings, if you are a smoker or have been at any point.